Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples
نویسندگان
چکیده
منابع مشابه
Advances in imaging secondary ion mass spectrometry for biological samples.
Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructu...
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This article is a concise review of the application of secondary ion mass spectrometry (SIMS) to the imaging of biological cells. The paper covers the various advantages and disadvantages of different approaches to SIMS analysis with respect to the information that can be gained from the interrogation of the cells. Current successes, pitfalls and future potential for SIMS in cell imaging are di...
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Identifying and separating subtly different biological samples is one of the most critical tasks in biological analysis. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is becoming a popular and important technique in the analysis of biological samples, because it can detect molecular information and characterize chemical composition. ToF-SIMS spectra of biological samples are enormou...
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mental standards, and by statistical and systematic errors in the measurement of x-ray lines and in the separation of line intensity from spectral background. The errors in estimating the characteristics of the detector system, with exception of deadtime effects, cancel when the emission from the specimen is divided by that from the standard. The estimate of achievable accuracy of EPMA and the ...
متن کاملLiquid Secondary Ion Mass Spectrometry
Liquid secondary-ion mass spectrometry (liquid SIMS) is an obsolescent ionization technique that revolutionized the analyses of large biological molecules in the 1980s. The term includes fast atom bombardment mass spectrometry (FAB-MS). The technique has been largely superseded by electrospray ionization. This account will cover the history of the technique, the principles of the operation, and...
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ژورنال
عنوان ژورنال: Annual Review of Biophysics
سال: 2009
ISSN: 1936-122X,1936-1238
DOI: 10.1146/annurev.biophys.050708.133634